Metabolic syndrome in HIV-infected patients viremic progressors and successfully treated

Abstract

Recently, increased survival of HIV-infected patients has been observed, enabled by antiretroviral therapy. ART has enabled a reduction in morbidity and mortality of these patients due to opportunistic infectious and neoplastic diseases; however, increased survival has been followed by an increase in the prevalence of chronic metabolic changes. Metabolic changes observed in patients undergoing ART, such as body fat distribution, are known to be associated with neuroendocrine metabolic disorders, especially insulin resistance and metabolic syndrome (MS), and increased cardiovascular risk. The aim of this study was to investigate the prevalence of MS among HIV-infected patients at different stages of infection: viremic and successfully treated. METHOD: medical records of HIV-infected patients followed at the Infectious Diseases Clinic, of the Clinical Hospital of the Federal University of Goiás Medical School were reviewed. MS was diagnosed based on the criteria recommended by National Cholesterol Education Program – Adult Treatment Panel (NCEP-ATP III). RESULTS: Among the 43 patients analyzed, 14 patients (32.5%) were diagnosed with MS, of which 7 were viremicprogressors and 7 were successfully treated. CONCLUSION: A prevalence of MS of 32.5% was found among HIV-infected patients followed at the HC-UFG Infectious Disease Clinic. There was no difference between the analyzed groups, which allows us to conclude that the higher risk of MS among these patients may not be associated with ART. Therefore, endocrinological and cardiological follow-up is essential as part of the treatment of these patients.