Genetics, diagnosis and prognosis tools of breast cancer in Brazil

Authors

  • Carolina Moraes Universidade Federal de Goiás (UFG) Autor
  • Natália Melo Universidade Federal de São Paulo (Unifesp) Autor
  • Fernanda Tacon Universidade Federal de Goiás (UFG) Autor
  • Carolina Mendonça Universidade Federal de Goiás (UFG) Autor
  • Waldemar Naves do Amaral Universidade Federal de Goiás (UFG) Autor

Keywords:

BREAST CANCER, GENETICS, BIOMARKERS, DIAGNOSE, PROGNOSIS

Abstract

Several evidences point to the influence of genetics in the development of diseases. Chromosoma l changes, deletions and changes in gene expression. Actively participate in the pathophysiology of diseases and guide clinical management and treatment. The detection of genetic changes and their association with phenotypic characteristics favor a new perspective of treatment and diagnosis for gynecological diseases related to breast tumors. This câncer is known for its genetic, molecular and histopathological complexity, which presentes variable clinical courses. Recent articles discuss which syndromes are associated with hereditary breast cancer, molecular classification, diagnosis, which are the molecular prognostic tools for detection, clinical management and treatment for breast tumors. Thus, the article aims to address the factors related to genetic, diagnosis and prognostic tools for breast cancer in Brazil.

References

INCA.Instituto Nacional de Câncer José Alencar Gomes da Silva. Estimativa 2020. Brasil: Ministério da Saúde/ Instituto Nacional de Câncer José Alencar Gomes da Silva (2020). Disponível em:http://www1.inca.gov. br/estimativa/2020/sintese-de-resultados-comentarios.asp. Acesso em: 17 de março de 2021.

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality wordwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018; 68: 394-424.

Feng Y, Spezia M, Huang S, Yuan C, Zang Z, Zhang L, et al. Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis. Genes and Diseases. 2018; 5(2): 77-106.

Bastos DR. Tisk factors related to breast cancer development. Mastology, 2019; 29(4): 218-223.

Chlebowski RT, Luo J, Anderson GL, Barrington W, Reding K, Simon MS, et al. Weight loss and breast cancer incidence in postmenopausal women. Cancer., 2018; 15, p. 205-212.

Ozmen V, Boylu S, Ok E, Canturk NZ, Celik V, Kapkac M, et al. Factors affecting breast cancer treatment delay in Turkey: a study from Turkish Federation of Breast Diseases Societies. Eur J Public Health. 2015;25(1):9-14.

Colditz GA., Kaphingst KA, Hankinson SE, Rosner B. Family history and risk of breast cancer: Nurses’ health study. Breast Cancer Research and Treatment. 2012; 133(3): 1097-104.

Wild JB, Hwang MJ, Jones G. A meta-analysis of consanguinity and breast cancer. Ir J Med Sci 2018; 187(4): 895-99.

Lazarev I, Flaschner M, Geffen DB, Ariad S. Breast cancer in Bedouin-Arab patients in southern Israel: epidemiologic and biologic features in comparison with Jewish patients. Asian Pac J Cancer Prev. 2014; 15(18):7533–37.

Larsen MJ, Thomassen M, Gerdes AM. Hereditary Breast Cancer: Clinical, Pathological and Molecular Characteristics. Breast CanCer: BasiC and CliniCal ResearCh., 2014; (3): p.145-55.

Pareja F, Marchiò C, Reis-Filho JS. Molecular diagnosis in breast cancer. Diagnostic Histopathology. 2018; 24 (2): 72-82.

Harvie M, Howell A, Evans DG. Can diet and lifestyle can prevent breast cancer: what is the evidence? Am Soc Clin Oncol Educ Book, 2015: e66-73.

Dowsett M, Folkerd E. Reduced progesterone levels explain the reduced risk of breast cancer in obese premenopausal women: a new hypothesis. Breast Cancer Research and Treatment. 2015 ; 149: 1 – 4.

Filha JGL, Miranda AKP, Júnior FFM, Costa HA, Figueiredo KRFV, Junior MNSO, et al. Influences of physical exercise on quality of life in two groups of breast cancer patients. Rev Bras Ciênc Esporte. 2016; 38(2): 107-14.

Silva APA, Ferreira TTC, Santos IBVM, Henrique GCF, Correia TY. A influência do exercício físico na qualidade de vida de adultos sobreviventes de câncer. Revista Eletrônica Acervo Saúde. 2019; (34), p. 1-8.

Coletta AM, Peterson SK, Gatus LA, Krause KJ, Schembre SM, Gilchrist SC et al. Diet, weight control, physical activity and risk of ovarian and breast cancer in women with pathogenic genetic variants of BRCA1 / 2: systematic review. Hered Cancer Clin Pract. 2020; 18 (1): 5.

Shield KD, Soerjomataram I, Rehm J. Alcohol use and breast cancer: a critical review. Alcohol Clin Exp Res. 2016; 40(6): 1166-81.

Howell A, Anderson AS, Clarke RB, Duffy SW, Evans DG, Garcia-Closas M et al. Determination of risks and prevention of breast cancer.Breast Cancer Res. 2014; 16: 446.

Liu Y, Ngugen N, Colditz GA. Links between alcohol consumption and breast cancer: a look at the evidence. Women’s Health. 2015; 11(1): 65-77

Ali AMG, Schmidt MK, Bolla M, Wang Q, Gago-Dominguez M, Castelao JE, et al. Alcohol consumption and survival after breast cancer diagnosis: meta-analysis based on the literature and collaborative data analysis for 29,239 cases. Cancer Epidemiology, Biomarkers & Prevention. 2014; 23(6): 934-45.

Cybulski C, Lubinski J, Huzarski T, Lynch HT, Randall SA, Neuhausen SL, et al. Prospective assessment of alcohol consumption and the risk of breast cancer in patients with BRCA1 and BRCA2 mutations. Breast Cancer Res Treat. 2015, 51(2):435-41.

Instituto Nacional De Câncer José Alencar Gomes Da Silva. Informativo Detecção Precoce. Rio de Janeiro: INCA, ano 6, n. 1, jan/abr. 2015b.

Delmonico L, Alves G, Amaral LFP. A biologia do câncer de mama e testes moleculares de prognóstico. Revista HUPE. 2015;14(Supl. 1): 59-65.

INCA.Instituto Nacional de Câncer José Alencar Gomes da Silva. A situação do câncer de mama no Brasil: síntese de dados dos sistemas de informação.Disponível em: https://www.inca.gov.br/sites/ufu.sti.inca.local/ files//media/document//a_situacao_ca_mama_brasil_2019.pdf. Acesso em: 17 de março de 2021.

Urban LABD, Chala LF, Bauab SP, Schaefer MB, Santos RP, Maranhão NMA, Kefalas AL, Kalaf JM, Ferreira CAP, Canella EO, Peixoto JE, Amorim HLE, Camargo Junior HSA. Recomendações do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem, da Sociedade Brasileira de Mastologia e da Federação Brasileira das Associações dDe Ginecologia e Obstetrícia para o rastreamento do câncer de mama. Radiol Bras. 2017;50(4):244–49. 86552155115

American College Radiology. Atlas BIRADS® do ACR: sistema de laudos e registro de dados de imagem da mama. 5. ed. Tradução de Angela Caracik. São Paulo: Colégio Brasileiro de Radiologia e Diagnóstico por Imagem, 2016.

Rogerio GV, Gilberto U, Tarciso S, Karinie MV. Ultrassografia mamária: aspectos contemporâneos. Com. Ciências Saúde – 22. 2011. Sup 1:S129- S140.

Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000,100(1): 57–70.

Harwansh RK, Deshmukh R. Breast cancer: An insight into its inflammatory, molecular, pathological and targeted facets with update on investigational drugs. Critical Reviews in Oncology / Hematology. 2020; 154: 103070.

Lakhani SR (ed.) WHO Classification of Tumours of Breast. Geneve: International Agency for Research on Cancer, 2012.

PuayHT, Ellis I, Allison K, Brogi E, Fox SB, Lakhani S. et al. The 2019 Word Health Organization classification of tumours of the breast. Histopathology, 2020; 77: 181-185.

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Published

2021-04-01

Issue

No. 59 (2021): Revista Goiana de Medicina

Section

Original Article

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Copyright (c) 2021 Goiana Journal of Medicine

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

1.
Moraes C, Melo N, Tacon F, Mendonça C, Amaral WN do. Genetics, diagnosis and prognosis tools of breast cancer in Brazil. Rev Goiana Med [Internet]. 2021 Apr. 1 [cited 2026 May 21];(59):6-11. Available from: https://amg.org.br/osj/index.php/RGM/article/view/84