Complicações tardias associadas ao uso de preenchedores dérmicos com ácido hialurônico em procedimentos estéticos faciais: uma revisão integrativa

Bruna  Zacharias Paolucci; Heloísa  Pacífico Gomes; Milena  de Campos Miranda; Gustavo  Machado Magalhães Filho; Guilherme  Tomas Luciano

Authors

Bruna Zacharias Paolucci Graduando em Medicina na Universidade Federal de Goiás, Goiânia/GO, Brasil. Autor https://orcid.org/0009-0004-9918-2744
Heloísa Pacífico Gomes Graduando em Medicina na Universidade Federal de Goiás, Goiânia/GO, Brasil. Autor https://orcid.org/0009-0002-7604-6796
Milena de Campos Miranda Graduando em Medicina na Universidade Federal de Goiás, Goiânia/GO, Brasil. Autor https://orcid.org/0009-0009-8932-1209
Gustavo Machado Magalhães Filho Graduando em Medicina na Universidade Federal de Goiás, Goiânia/GO, Brasil. Autor https://orcid.org/0009-0001-4415-2917
Guilherme Tomas Luciano Graduando em Medicina na Universidade Federal de Goiás, Goiânia/GO, Brasil. Autor https://orcid.org/0009-0002-9281-0897

Keywords:

Adverse complications, Dermal fillers, Facial aesthetics, Hyaluronic Acid, Patient safety

Abstract

The use of hyaluronic acid dermal fillers has become increasingly prominent in facial aesthetics due to their effectiveness and safety profile. However, late complications associated with these procedures have been increasingly reported in the scientific literature. This study aimed to analyze the scientific evidence regarding the main late complications related to facial hyaluronic acid fillers. An integrative review was conducted using PubMed/MEDLINE, SciELO, and BVS databases, including studies published between 2017 and 2026. The findings demonstrated that intermittent delayed edema, inflammatory nodules, granulomas, hypersensitivity reactions, and biofilm-associated complications are the most frequently reported adverse events, being associated with technical factors, biomaterial characteristics, and systemic patient conditions. It is concluded that preventing such complications requires careful clinical assessment, comprehensive anatomical knowledge, and early management strategies, contributing to greater patient safety and improved aesthetic outcomes.

References

Lee SY, Youn CS, Park KY. Midface volumization and skin quality enhancement with a hyaluronic acid-polynucleotide hybrid filler: 24-week prospective open-label study. J Dermatolog Treat. 2026;37(1):2621537. doi:10.1080/09546634.2026.2621537.

Urdiales-Gálvez F, Delgado NE, Figueiredo V, Lajo-Plaza JV, Mira M, Ortíz-Martí F, Del Rio-Reyes R, Romero-Álvarez N, Ruiz del Cueto S, Segurado MA, Villanueva Rebenaque C. Preventing the complications associated with the use of dermal fillers in facial aesthetic procedures: an expert group consensus report. Aesthetic Plast Surg. 2017;41(3):667-77. doi:10.1007/s00266-017-0798-y.

Piton LMM, Freitas MFL, Oliveira CMS, Silva CF. Principais complicações associadas ao preenchimento facial com ácido hialurônico: uma revisão de literatura. Rev Ibero-Am Humanid Cienc Educ. 2025;11(11):5681-91. doi:10.51891/rease.v11i11.22348.

Ciaramicolo NO, Bisson GB, Piedade EFDS, Osny FJ. Late facial edema after lip filling with hyaluronic acid: possible association with the use of Ozempic. J Craniofac Surg. 2024;35(7):2110-2. doi:10.1097/SCS.0000000000010588.

Qiu H, Xu J, Wu X, Wu Y, Chen X, Zhong P, Wang F, Lin Q, Li F, Xu T. Clinical outcomes of intense pulsed light combined with non-crosslinked sodium hyaluronate, tranexamic acid and vitamin C mesotherapy for facial photoaging: a retrospective study. J Dermatolog Treat. 2026;37(1):2609454. doi:10.1080/09546634.2025.2609454.

Shturman I, Garzón H, Coimbra D, Villafranca J, Zimbres S, Pyke MLA, Van Der Graaff I, Dabronzo ML. Minimally invasive aesthetic treatments for the corrective patient archetype: transforming lives. Aesthetic Plast Surg. 2026;50(11):4461-75. doi:10.1007/s00266-026-05747-w.

Bettiol NB, de Carvalho FA, Siessere S, Romero GDA, de Menezes M, Martini CCJ, Mazzi-Chaves JF, Magri LV, Regalo SCH, Palinkas M. Assessment of orofacial function after mandibular angle harmonization with hyaluronic acid: an observational longitudinal study. Dent J (Basel). 2026;14(4):241. doi:10.3390/dj14040241.