Anestesia geral balanceada em inserção de membrana de células tronco em fistula bronco pleural: relato de caso

Felipe  Mendes Faria; Larissa Manzan De Alcantara Borges; Matheus  Silva De Oliveira; Plinio  Almeida Pinheiro de Belém; Gustavo  Siqueira Elmiro; Giulliano  Gardenghi

doi:10.63162/v66n68e25619

Authors

Felipe Mendes Faria Centro de Ensino e Treinamento da Clínica de Anestesia (CET - CLIANEST), Goiânia/GO, Brasil Autor https://orcid.org/0000-0003-1498-906X
Larissa Manzan De Alcantara Borges Centro de Ensino e Treinamento da Clínica de Anestesia (CET - CLIANEST), Goiânia/GO, Brasil Autor https://orcid.org/0009-0001-6623-2918
Matheus Silva De Oliveira Centro de Ensino e Treinamento da Clínica de Anestesia (CET - CLIANEST), Goiânia/GO, Brasil Autor https://orcid.org/0000-0002-9936-1556
Plinio Almeida Pinheiro de Belém Centro de Ensino e Treinamento da Clínica de Anestesia (CET - CLIANEST), Goiânia/GO, Brasil Autor https://orcid.org/0009-0006-7668-0702
Gustavo Siqueira Elmiro Centro de Ensino e Treinamento da Clínica de Anestesia (CET - CLIANEST), Goiânia/GO, Brasil Autor https://orcid.org/0000-0003-2113-8757
Giulliano Gardenghi Centro de Ensino e Treinamento da Clínica de Anestesia (CET - CLIANEST), Goiânia/GO, Brasil; Hospital ENCORE, Aparecida de Goiânia/GO, Brasil Autor https://orcid.org/0000-0002-8763-561X

DOI:

https://doi.org/10.63162/v66n68e25619

Keywords:

Bronchial fistula, Stem cells, Thoracic surgery, Wound healing, Lung

Abstract

Bronchopleural fistula is a multifactorial pathological condition that remains difficult to resolve and is associated with high morbidity. With advances in medical science, there has been a growing number of studies on the use of stem cell therapy in the treatment of diseases that previously had few alternatives to achieve a cure. Mesenchymal stem cells have emerged as a promising therapeutic component, primarily due to their intrinsic ability to secrete pro-angiogenic cytokines and modulate the tissue microenvironment, thereby directing recruited cells toward effective wound healing. This case report describes an elderly female patient with multiple comorbidities who underwent closure of a bronchial fistula using a platelet-rich fibrin and leukocyte membrane (PRFL), obtained via centrifugation of mesenchymal cells through a one-step technique during the surgical procedure. The intervention was performed under balanced general anesthesia and required heightened vigilance due to several episodes of apnea needed for membrane placement. The procedure was completed successfully, with favorable outcomes observed in all phases.

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